Modafinil
Half-life
~12-15 hours
What is Modafinil?
Wakefulness-promoting agent (eugeroic). Increases dopamine reuptake inhibition. Prescription required.
How Modafinil works
Wake-promoting DAT inhibition with orexin/histamine network activation increases alertness without classic amphetamine profile.
Benefits & uses
Common uses: Narcolepsy, shift work sleep disorder, cognitive enhancement, focus, alertness.
Modafinil dosage
- Reference range
- Prescription-dependent (commonly 100–200 mg in the morning); doctor-directedClinical or reference range, not a personal recommendation.
Modafinil half-life
~12-15 hours
Modafinil side effects
Headaches, nausea, insomnia if taken too late, anxiety, reduced appetite.
- Insomnia
- Headache
- Anxiety and appetite suppression
- Insomnia if taken late
- Anxiety/jitters
- Reduced appetite
- Rare serious rash (seek care)
Warnings & monitoring
- Prescription medication — requires a doctor. Can reduce hormonal-contraceptive efficacy. Rare but serious skin reactions — stop and seek care if rash appears.
Modafinil interactions
with Birth Control
Avoid · moderateModafinil induces CYP3A4, reducing hormonal contraceptive efficacy. Failure rate increases significantly without backup method.
Timing: Use backup contraception during modafinil use
with Adderall
Caution · moderateModafinil's eugeroic effect plus amphetamine stimulation produces excessive cardiovascular load and disrupts sleep architecture for 24+ hours.
Timing: Same-day stacking is risky — separate dosing
with Testosterone
CompatibleModafinil (a wakefulness-promoting agent) does not directly interact with testosterone. Some users employ modafinil for cognitive performance or shift work alongside TRT. Monitor sleep quality.
Timing: Modafinil in the morning; does not interact with testosterone administration
Track Modafinil in Protokol.
Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.
