SupplementEmergingLiver Support
Milk Thistle (Silymarin)
Also known as Milk Thistle
Half-life
~6 hours
What is Milk Thistle (Silymarin)?
Standardized silymarin extract with long history of hepatoprotective use. Weak but consistent liver support.
How Milk Thistle (Silymarin) works
Silybin (main active component) is a flavonolignin that inhibits lipid peroxidation in hepatocyte membranes, reduces oxidative stress, stimulates ribosomal RNA synthesis for liver regeneration, and inhibits hepatotoxin binding.
Benefits & uses
- Liver protection/support
- Antioxidant
- Supports liver during oral-compound use
- May aid liver enzyme recovery
Common uses: Liver protection, antioxidant, anti-inflammatory liver support, hangovers.
LongevityRecovery
Milk Thistle (Silymarin) dosage
- Typical dose
- 200–400 mg silymarin (standardized 70–80% silybin content) three times daily with meals.
Milk Thistle (Silymarin) half-life
~6 hours (silymarin in plasma)
Milk Thistle (Silymarin) side effects
Very safe. Mild laxative/GI effect. May modestly affect CYP enzyme metabolism.
- Mild GI effects (diarrhea rarely)
- May modestly inhibit CYP2C9/3A4 — drug interactions possible at high doses
- Generally very safe for long-term use
- Generally well tolerated
- Mild GI/laxative effect
Track Milk Thistle (Silymarin) in Protokol.
Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.
