PeptideEmergingCosmetic
Matrixyl
Cosmetic peptide (topical, palmitoyl pentapeptide-4)
Typical dose
topical serum ~3–8%
topical · not injected
Half-life
n/a
What is Matrixyl?
Cosmetic collagen-stimulating peptide (matrikine); used topically.
How Matrixyl works
A matrikine-mimicking peptide (lipid-conjugated for better skin penetration) that signals fibroblasts to upregulate collagen and glycosaminoglycan synthesis.
Benefits & uses
- Stimulates collagen synthesis (topically)
- Reduces wrinkle depth (studies showed up to ~30% over 30 days)
- Improves skin firmness/texture
Common uses: Topical skincare — anti-aging, collagen, wrinkles.
Matrixyl dosage
- Typical dose
- Topical — used in serums at ~3–8%. Not injected.
Matrixyl half-life
n/a (topical)
Matrixyl side effects
- Very well tolerated topically
- Rare mild irritation
Warnings & monitoring
- Topical cosmetic use — very safe. Penetration is improved by the palmitoyl group but still limited (efficacy caveat).
Preparation & storage
- Preparation
- Dissolved into a topical serum base — not injected.
- Reconstitution
- Dissolved into a topical serum base — not injected.
Track Matrixyl in Protokol.
Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.
