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Supplement

Magnesium Bisglycinate

Half-life

~42 days

What is Magnesium Bisglycinate?

Two glycine molecules chelated to one magnesium ion for maximum GI tolerance and bioavailability.

How Magnesium Bisglycinate works

Two-glycine chelation creates a completely neutral molecule absorbed via peptide transporters (not magnesium-specific channels), avoiding competition with other minerals and achieving the highest GI tolerance of all magnesium forms.

Benefits & uses

Common uses: Sleep quality, anxiety, muscle relaxation, HRV improvement.

Magnesium Bisglycinate dosage

Typical dose
200–400 mg elemental magnesium at bedtime.

Magnesium Bisglycinate half-life

~42 days (tissue magnesium)

Magnesium Bisglycinate side effects

Extremely well tolerated. Virtually no laxative effect at recommended doses.

  • Virtually no GI side effects — best tolerated magnesium form
  • Drowsiness (beneficial at bedtime)

Track Magnesium Bisglycinate in Protokol.

Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.

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For research and educational purposes only. This page is not medical advice and is not a recommendation to use any compound. Many compounds listed are not approved for human use, and some are prescription-only or controlled in your jurisdiction. Dosing figures are reference or observational reports. Talk to a qualified healthcare provider before starting, stopping, or changing anything. Protokol is for tracking purposes only.