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SupplementEmergingEstrogen Management

I3C (Indole-3-Carbinol)

Also known as I3C

What is I3C (Indole-3-Carbinol)?

Indole-3-carbinol — a compound from cruciferous vegetables (broccoli, kale) that supports healthy estrogen metabolism. DIM is its downstream product.

How I3C (Indole-3-Carbinol) works

Converts (partly to DIM) in the stomach and shifts estrogen metabolism toward favorable 2-hydroxy metabolites over less-favorable ones.

Benefits & uses

  • Supports healthy estrogen metabolism
  • May support hormonal balance
  • Antioxidant/cruciferous support

Common uses: Estrogen metabolism support, hormonal balance, often in TRT/PCT stacks.

Longevity

I3C (Indole-3-Carbinol) dosage

Typical dose
200–400 mg daily

I3C (Indole-3-Carbinol) side effects

  • Generally well tolerated
  • Mild GI upset

Commonly stacked with

Calcium D-GlucarateDIM (Diindolylmethane)

Track I3C (Indole-3-Carbinol) in Protokol.

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More Estrogen Management

For research and educational purposes only. This page is not medical advice and is not a recommendation to use any compound. Many compounds listed are not approved for human use, and some are prescription-only or controlled in your jurisdiction. Dosing figures are reference or observational reports. Talk to a qualified healthcare provider before starting, stopping, or changing anything. Protokol is for tracking purposes only.