Supplement
Grape Seed Extract
Half-life
~2 hours
What is Grape Seed Extract?
Oligomeric proanthocyanidins (OPCs) from grape seeds with potent antioxidant and cardiovascular benefits.
How Grape Seed Extract works
OPCs inhibit oxidation of LDL, enhance nitric oxide production in endothelium, cross-link collagen fibers to improve vascular wall integrity, and inhibit NF-kB inflammatory signaling.
Benefits & uses
Common uses: Antioxidant protection, blood pressure support, venous insufficiency, collagen protection.
Grape Seed Extract dosage
- Typical dose
- 100–300 mg/day standardized to 95% OPCs. Most benefit seen in cardiovascular and venous health applications.
Grape Seed Extract half-life
~2 hours (OPCs in plasma)
Grape Seed Extract side effects
Very safe. Mild blood thinning at high doses. Avoid with anticoagulants.
- Very mild anticoagulant effect at high doses — caution with warfarin
- Occasional headache
- Generally very safe
Track Grape Seed Extract in Protokol.
Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.
