PeptideAnecdotalLongevity
FOXO4-DRI
Senolytic peptide (experimental)
Typical dose
pulsed, experimental
SubQ · dosing not standardized
Half-life
short
What is FOXO4-DRI?
Senolytic peptide that targets senescent cells; highly experimental, dosing unestablished.
How FOXO4-DRI works
A D-retro-inverso peptide that disrupts the FOXO4–p53 interaction, triggering apoptosis selectively in senescent cells (proven in aged mice; no human trials).
Benefits & uses
- Selectively clears senescent ('zombie') cells
- Anti-aging / vascular-aging interest (animal data)
- Longevity research
Common uses: Longevity / senescent-cell clearance (experimental).
FOXO4-DRI dosage
- Typical dose
- Highly experimental senolytic; dosing not standardized — used in short pulses in research. Frame very conservatively.
FOXO4-DRI half-life
short
FOXO4-DRI side effects
- No human safety data
- Unknown human side effects
- Animal studies only
Warnings & monitoring
- 🔴 Experimental senolytic — animal data only, NO human trials. Inducing apoptosis is a powerful mechanism with unknown human risks. Research/informational only.
Preparation & storage
- Preparation
- Mix a 10 mg vial with 2 mL bac water → 5 mg/mL. Highly experimental.
- Reconstitution
- Reconstitute a 10 mg vial with 2 mL BAC water → 5 mg/mL.
Track FOXO4-DRI in Protokol.
Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.
