Dutasteride
5-AR Inhibitor
Also known as Avodart
Half-life
~4-5 weeks
What is Dutasteride?
Dual type I/II 5-alpha-reductase inhibitor with stronger DHT suppression than finasteride.
How Dutasteride works
Inhibits both 5-alpha-reductase isoenzymes, producing prolonged systemic DHT reduction.
Benefits & uses
Common uses: Male-pattern hair loss (stronger); BPH; DHT control.
Dutasteride dosage
Protokol doesn't recommend doses for prescription or controlled compounds. Any figures below are reference or observational reports — dosing should be set with a qualified clinician.
- Reference range
- Literature reports ~0.5 mg dailyClinical or reference range, not a personal recommendation.
Dutasteride half-life
~4-5 weeks
Dutasteride side effects
- Sexual dysfunction
- Gynecomastia risk
- Long washout due to long half-life
- Sexual side effects
- Mood changes
- Longer-lasting than finasteride due to long half-life
Warnings & monitoring
- Prescription medication — requires a doctor. Not for use by/around pregnant women. Long half-life. Lowers PSA.
Monitoring: Same as finasteride; longer half-life (effects/sides persist longer).
Dutasteride interactions
with Finasteride
Avoid · moderateBoth block 5-alpha reductase. Combining intensifies sexual side effects and the rare risk of post-finasteride-syndrome without meaningful additional DHT reduction.
Timing: Do not combine 5-AR inhibitors
with Testosterone
Caution · moderateDutasteride inhibits both 5-alpha reductase type 1 and 2, providing more complete DHT suppression than finasteride. More potent — greater risk of sexual side effects. Discuss with physician.
Timing: Dutasteride taken daily; stronger DHT suppression than finasteride
Track Dutasteride in Protokol.
Log doses, model half-lives, check interactions, and line it all up against your bloodwork. Free on iPhone and Android.
